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Yersinia pestis plague

Yersinia Pestis (Plague) - Johns Hopkins Center for Health

Plague is a widespread zoonotic disease that is caused by Yersinia pestis and has had devastating effects on the human population throughout history. Disappearance of the disease is unlikely due to the wide range of mammalian hosts and their attendant fleas Summary Plague is an acute, often fatal, and potentially epidemic re-emerging disease caused by infection with the gram-negative bacterium Yersinia pestis Lehmann and Neumann, 1896. However, plag.. Plague is an infection caused by the invasive Gram-negative bacillus Yersinia pestis. It is among the most dramatic bacterial diseases in human history [ 1 ]. In spite of its disappearance in most developed countries, plague still represents a significant public health problem in many regions of the world [ 2 ] Yersinia pestis a zoonotic bacterium is the causative agent of Plague. Morphology: Yersinia pestis is a gram-negative rod-shaped bacteria that exhibit bipolar staining with special stains such as Wright, Giemsa, Wayson, or methylene blue stains

The etiological agent of plague is the gram-negative bacterium Yersinia pestis , discovered by Alexandre Yersin in 1894 during an outbreak of plague in Hong Kong . The plague left a significant mark in the history of mankind: three world plague pandemics led to significant changes in the social and economic structure of society The bacteria that cause plague, Yersinia pestis, maintain their existence in a cycle involving rodents and their fleas.Plague occurs in rural and semi-rural areas of the western United States, primarily in semi-arid upland forests and grasslands where many types of rodent species can be involved Plague is an infectious disease caused by the bacterium Yersinia pestis. Symptoms include fever, weakness and headache. Usually this begins one to seven days after exposure. There are three forms of plague, each affecting a different part of the body and causing associated symptoms The plague bacteria, Yersinia pestis, is transmitted to humans through the bites of fleas that have previously fed on infected animals, such as: Rats; Mice; Squirrels; Rabbits; Prairie dogs; Chipmunks; Voles; The bacteria can also enter your body if a break in your skin comes into contact with an infected animal's blood Plague is a disease that affects humans and other mammals. It is caused by the bacterium, Yersinia pestis. Humans usually get plague after being bitten by a rodent flea that is carrying the plague bacterium or by handling an animal infected with plague. Plague is infamous for killing millions of people in Europe during the Middle Ages

Plague (Yersinia pestis) CD

  1. Yersinia pestis är bakterien som orsakar pest. Den är en gramnegativ, stavformad och fakultativ anaerob bakterie inom familjen Enterobacteriaceae. Den kan infektera djur och människor, där pestloppan är den främsta spridaren till människan, och bakterien orsakar pest som uppträder som böldpest, lungpest eller blodpest. Y. pestis upptäcktes år 1894 av Alexandre Yersin och orsakade bland annat digerdöden som tog död på två tredjedelar av Europas befolkning på 1300.
  2. The association of historical plague pandemics with Yersinia pestis remains controversial, partly because the evolutionary history of this largely monomorphic bacterium was unknown. The microevo-lution of Y. pestis was therefore investigated by three different multilocus molecular methods, targeting genomewide synony
  3. The Plague: Yersinia pestis - YouTube. The Plague: Yersinia pestis. Watch later. Share. Copy link. Info. Shopping. Tap to unmute. If playback doesn't begin shortly, try restarting your device
  4. Plague is an infectious disease caused by the bacteria Yersinia pestis, a zoonotic bacteria, usually found in small mammals and their fleas. It is transmitted between animals through fleas. Humans can be infected through
  5. Yersinia pestis (Y. pestis) (formerly Pasteurella pestis) is a gram-negative, non-motile, rod-shaped, coccobacillus bacterium, without spores that is related to both Yersinia pseudotuberculosis and Yersinia enterocolitica.It is a facultative anaerobic organism that can infect humans via the Oriental rat flea (Xenopsylla cheopis). It causes the disease plague, which caused the First plague.
  6. Yersinia pestis - The Plague : Microbiology LecturesThe Plague, The Black Death, The Plague of Justinian they are all caused by the bacteria known as Yersini..
Pathogenic Yersiniae | British Society for Immunology

Plague, caused by Yersinia pestis, has 3 clinical forms. Bubonic plague (BP), the predominant form, results from a flea bite. If BP is untreated, Y. pestis can enter the bloodstream, causing septicemic plague, and/or spread to the lungs, causing secondary pneumonic plague (PP) Nature Communications - Yersinia pestis, which evolved from a gastrointestinal pathogen, causes pneumonic and bubonic plague. Here Zimbler et al. show that the gain of a single protein enabled Y. Plague is transmitted to humans by fleas or by direct exposure to infected tissues or respiratory droplets. Laboratory Criteria For Diagnosis . Isolation of Yersinia pestis from a clinical specimen, OR; Fourfold or greater change in serum antibody to Y. pestis; Case Classification Probabl Black Plague (Yersinia pestis)- Brutal Comments. Black Plague (Yersinia pestis)- Brutal Pre game bonuses: ATP Boost Genetic Mimic Suppression Extremophile Translesion+ ~ Start in: Saudi Arabia 26-4-2014-Plague start date (I specced into nothing until i hit about 30-35 points) 08-09-2014 Pneumonic plague Air 1. A 5,000-year-old Yersinia pestis genome (RV 2039) is reconstructed from a hunter-fisher-gatherer (5300-5050 cal BP) buried at Riņņukalns, Latvia. Our data do not support the scenario of a prehistoric pneumonic plague pandemic, as suggested previously for the Neolithic decline

How Yersinia Pestis Evolved its Ability to Kill Millions

Yersinia pestis and plague: an updated view on evolution

Abstract. Over the last few years, genomic studies on Yersinia pestis, the causative agent of all known plague epidemics, have considerably increased in numbers, spanning a period of about 5,000 y.Nonetheless, questions concerning historical reservoirs and routes of transmission remain open Yersinia Pestis. Yersinia pestis causes plague, Y. pseudotuberculosis causes mainly mesenteric lymphadenitis and septicemia, and Y. enterocolitica, which is the most prevalent species among humans, can cause a wide range of human diseases varying from mild diarrhea to mesenteric lymphadenitis Yersinia pestis, formerly pasteurella pestis, Bacteria responsible for the plague. Seen under optical microscopy X 1000. Colonial morphology of Gram-negative Yersinia pestis bacteria grown 72 hours on a medium of sheep's blood agar , 2010 Abstract. We analyzed epidemiologic characteristics and distribution of 1,067 human plague cases and 5,958 Yersinia pestis isolates collected from humans, host animals, and insect vectors during 1950-2019 in 4 Marmota plague foci in China. The case-fatality rate for plague in humans was 68.88%; the overall trend slowly decreased over time but fluctuated greatly Yersinia pestis is a Gram-negative coccobacillus which belongs to a family of bacteria called the Enterobacteriaceae.. It causes a disease called plague, which is transmitted by rodents, mainly rats, as well as prairie dogs, and their fleas. Plague is highly contagious, and there have been three major pandemics in human history - one of them, known as the

Yersinia pestis and the plague - PubMe

Access Plague (Yersinia pestis) case definitions; uniform criteria used to define a disease for public health surveillance Plague is a serious bacterial infection that's transmitted primarily by fleas. The organism that causes plague, Yersinia pestis, lives in small rodents found most commonly in rural and semirural areas of Africa, Asia and the United States Plague, one of the most devastating diseases of human history, is caused by Yersinia pestis.In this study, we analyzed the population genetic structure of Y. pestis and the two other pathogenic Yersinia species, Y. pseudotuberculosis and Y. enterocolitica.Fragments of five housekeeping genes and a gene involved in the synthesis of lipopolysaccharide were sequenced from 36 strains representing. The Gram-negative bacterium Yersinia pestis is responsible for deadly plague, a zoonotic disease established in stable foci in the Americas, Africa, and Eurasia. Its persistence in the environment. Yersinia pestis has caused at least three human plague pandemics. The second (Black Death, 14-17th centuries) and third (19-20th centuries) have been genetically characterised, but there is only a limited understanding of the first pandemic, the Plague of Justinian (6-8th centuries). To address this gap, we sequenced and analysed draft.

The recent Article by David Wagner and colleagues1 reports the sequencing of a draft genome of Yersinia pestis extracted from two bodies interred at Aschheim, Bavaria, in the late 6th century CE.2 However, this study goes beyond the genetic analysis of these remains to make claims about the three known plague pandemics: the Justinianic (541-750), the Black Death, which began in the 1340s. Yersinia pestis. Riskklass 3 [1]. Sjukdom Böldpest, blodpest eller lungpest. (Bubonic plague, septicemic plague, pneumonic plague (eng.)). Sjukdomen är anmälnings- och smittspårningspliktig enligt smittskyddslagen och inträffade fall anmäls till smittskyddsläkaren i regionen och till Folkhälsomyndigheten. Allmän information Gram. Yersinia pestis is a vector-borne pathogen. People usually get infected by being bitten by fleas that carry the bacteria. These fleas are carried by rodents. In the Middle Ages, human homes and places of work were inhabited by rats that carried plague infected fleas. For more information about the Black Death email us here The picture shows a cutaway of the plague bacterium, Yersinia pestis, with many of the main components illustrated. The cell is drawn to scale and in this diagram measures 700nm in diameter and 2100nm in length (excluding the outer lumpy coat). The image above is 300 pixels across and the original is 2,277 pixels across and lacks all labels Yersinia pestis: The Plague When someone mentions the plague, the Black Death often leaps to mind: an infamous, decimating disease that we tend to associate with the medieval period. However, since the beginning of recorded history the plague has sinisterly spread across the globe and wiped out up to 30-40% of the world's population three times, as well as hundreds of smaller outbreaks

The strain of bacteria that caused the Great Plague of London in 1665 has been identified for the first time. Scientists recovered DNA of Yersinia pestis—known to have been responsible for the. Plague is caused by Yersinia pestis bacteria. It can be a life-threatening infection if not treated promptly. Plague has caused several major epidemics in Europe and Asia over the last 2,000 years. Plague has most famously been called the Black Death because it can cause skin sores that form black scabs

CDC Facts About Plagu

Yersinia pestis has caused at least three human plague pandemics. The second (Black Death, 14-17th centuries) and third (19-20th centuries) have been genetically characterised, but there is only a limited understanding of the first pandemic, the Plague of Justinian (6-8th centuries) While studying Yersinia pestis, the bacteria responsible for epidemics of plague such as the Black Death, scientists found a single small genetic change that fundamentally influenced the evolution. Yersinia pestis, the causative agent of plague, has been prevalent among humans for at least 5000 years, being accountable for several devastating epidemics in history, including the Black Death.Analyses of the genetic diversity of ancient strains of Y. pestis have shed light on the mechanisms of evolution and the spread of plague in Europe

Overview of Plague. First Described: Descriptions of plague date back to around 1300 bc.The causative agent was isolated in 1894, in Hong Kong (Alexandre Yersin). 1 Cause: Yersinia pestis, a gram-negative coccobacillus (family Enterobacteriaceae) Affected Hosts: Y. pestis causes disease in rodents, rabbits, wild carnivores, domestic dogs and cats, and humans Yersinia pestis used in an aerosol attack could cause cases of the pneumonic form of plague. One to six days after becoming infected with the bacteria, people would develop pneumonic plague. Once people have the disease, the bacteria can spread to others who have close contact with them Spyrou et al. have sequenced historical Yersinia pestis genomes from victims of the Black Death and subsequent outbreaks in Europe. Their data suggest a connection between the Black Death and the modern-day plague pandemic as well as the persistence of plague in Europe between the 14th and 18th centuries RESEARCH ARTICLE Temporal phylogeography of Yersinia pestis in Madagascar: Insights into the long-term maintenance of plague Amy J. Vogler1, Voahangy Andrianaivoarimanana2, Sandra Telfer3, Carina M. Hall1, Jason W. Sahl1, Crystal M. Hepp1, Heather Centner1, Genevieve Andersen1, Dawn N. Birdsell1, Lila Rahalison2, Roxanne Nottingham1, Paul Keim1,4, David M. Wagner1*, Minoarisoa Rajerison2* 1.

Plague (Yersinia pestis) Communicable Disease Management Protocol - Plague July 2018 1 1. Case Definition 1.1 Confirmed Case: Clinical evidence of illness* with laboratory confirmation of infection: Isolation of Yersinia pestis from body fluids (e.g., fluid from buboes, throat swab, sputum, blood) O Plague, caused by Yersinia pestis, has 3 clinical forms.Bubonic plague (BP), the predominant form, results from a flea bite. If BP is untreated, Y. pestis can enter the bloodstream, causing septicemic plague, and/or spread to the lungs, causing secondary pneumonic plague (PP). Individuals with secondary PP can transmit Y. pestis to other individuals via respiratory droplets, resulting in. The plague is an extremely serious zoonotic (transmissible from animals to humans) infection caused by the bacteria Yersinia pestis. This is the bacteria that is believed to have been responsible for the Black Death which wiped out a 30-60% of the population of Europe from 1346 Yersinia pestis (Plague) Unless otherwise noted, all information presented in this article is derived from Inglesby TV, Dennis DT, Henderson DA, et al., for the Working Group on Civilian Biodefense. Plague as a biological weapon: medical and public health management. JAMA. 2000;283(17):2281-2290. Updated October 19, 2011. Backgroun Y. pestis, the causative agent of plague, has a protracted history, being described in epidemics and pandemics since biblical times. In the Middle Ages, it was estimated to have killed up to 40% of the European population. In more recent Yersinia pestis . Bioterroris

Video: Yersinia pestis--etiologic agent of plague

Black Death and The Plague - the plague is an infectious disease caused by a bacterium called Yersinia pestis. The Black Death is one huge plague event (pandemic) in history This plague is believed to have been the first rise of the bubonic plague and DNA research by Wagner et. al, has been conducted on bodies from the era and the bacteria Yersinia pestis was found. In order to determine if Y. pestis was the cause of this plague the researchers sequenced and analyzed genomes of Y. pestis , which were taken from two specific individuals known to have died in this. Yersinia pestis causes an infection called plague. Plague is relatively common in rodents, even today. In North America it primarily affects prairie dog colonies, killing anywhere up to 100% of infected populations.However, most rodents become partially resistant and populations are usually controlled rather than wiped out Welcome everyone to today's class, we are talking about one of my idols, and possibly the grim reaper in physical form, Yersinia pestis bacterium.We will discuss how the black plague spread, who caused the black plague Yersinia pestis DNA was recently detected in human remains from 2 ancient plague pandemics in France and Germany. We have now sequenced Y. pestis glp D gene in such remains, showing a 93-bp deletion specific for biotype Orientalis

Yersinia Pestis: Plague - BSL3 and BSL4 Agents - Wiley

Plague (Yersinia pestis) Description of illness: Plague is a disease that affects humans and other mammals, caused by the bacterium, Yersinia pestis. Humans usually contract plague after being bitten by a rodent flea that is carrying the plague bacterium or by handling an animal infected with plague. Antibiotics are effective in treating plague. Sylvatic plague, caused by the bacterium Yersinia pestis, is periodically responsible for large die-offs in rodent populations that can spillover and cause human mortalities.In the western US, prairie dog populations experience nearly 100% mortality during plague outbreaks, suggesting that multiple transmission pathways combine to amplify plague dynamics In this regard, the 1346-1353 Yersinia pestis-caused Black Death pandemic, with continued plague outbreaks spanning several hundred years, is one of the most devastating recorded in human history. To investigate the potential impact of Y. pestis on human immunity genes, we extracted DNA from 36 plague victims buried in a mass grave in Ellwangen, Germany in the 16th century

The invasive pathogen Yersinia pestis disrupts host blood

Yersinia pestis (tidigare känd som Pasteurella pestis) är bakterien som orsakar pest.Den är en gramnegativ, stavformad och fakultativ anaerob bakterie inom familjen Enterobacteriaceae.Den kan infektera djur och människor, där pestloppan (Xenopsylla cheopis) är den främsta spridaren till människan, och bakterien orsakar pest som uppträder som böldpest, lungpest eller blodpest Plague is a deadly infectious disease caused by the bacterium Yersinia pestis 1,2. Post-genomic analyses confirmed that Y. pestis was derived from the environmental bacteria Yersinia. Yersinia pestis synonyms, Yersinia pestis pronunciation, Yersinia pestis translation, English dictionary definition of Yersinia pestis. Noun 1. Yersinia pestis - a bacillus bacterium that causes the plague; aerosolized bacteria can be used as a bioweapon B, bacillus - aerobic rod-shaped.. Abstract Although Mongolia is regarded as one of the possible places of plague radiation, only few data are available from Mongolian Yersinia pestis strains. In this study a total of 100 Mongolian Y. pestis strains isolated from wild mammals and their parasites between the years 1960 and 2007 were analyzed for their phenotype. All strains grew well on selective Cefsulodin-Irgasan-Novobiocin. Plague, a fatal disease caused by the bacillus, Yersinia pestis, still affects resources-limited countries. Information on antibody response to plague infection in human is scarce. Anti-F1 Ig G are among the known protective antibodies against Y. pestis infection. As a vaccine preventable disease, knowledge on antibody response is valuable for the development of an effective vaccine to reduce.

The conference of experts of the Anti-Plague Establishments of the Soviet Union (Saratov, 1985) recommended classifying all of the variants of the plague pathogen that were isolated from the territory of the Former Soviet Union and Mongolia into the subspecies Yersinia pestis subsp. pestis, Yersinia pestis subsp. altaica, Yersinia pestis. Plague. Plague is a severe bacterial infection that may cause death. Plague is caused by the bacteria Yersinia pestis. Rodents, such as rats, carry the disease. It is spread by their fleas. People can get plague when they are bitten by a flea that carries the plague bacteria from an infected rodent. In rare cases, people get the disease when. Yersinia pestis Siphonaptera Rodentia Norovirus Sciuridae Ctenocephalides Pasteurella Saimiri. Diseases 11. Plague Foodborne Diseases Gastroenteritis Salmonella Food Poisoning Rodent Diseases Cross Infection Zoonoses Communicable Diseases, Emerging Bacterial Infections Hantavirus Infections Fever. Chemicals and Drugs 2 Plague bacterium Yersinia pestis Plague bacterium Yersinia pestis, scientifically accurate 3D illustration showing structure of the cell with DNA, plasmids and ribosomes yersinia pestis stock pictures, royalty-free photos & images. Enterobacteria

Yersinia pestis - a species causing plague. Synonym(s): Kitasato bacillus. Yersinia pseudotuberculosis - a species causing pseudotuberculosis in birds and rodents; rarely in humans Synonym(s): Pasteurella pestis. yersiniosis - infectious disease caused by Yersinia enterocolitica Plague is caused by the gram-negative bacterium Yersinia pestis. Symptoms are either severe pneumonia or massive lymphadenopathy with high fever, often progressing to septicemia. Diagnosis is epidemiologic and clinical, confirmed by culture and serologic testing

Yersinia Pestis and Medical Cannabis Treatment. Most commonly called the Black Death due to the dark scabs and sores it causes, the plague yersinia pestis has caused significant epidemics across Europe and Asia throughout the past 2,000 years, according to Harvard Health Publishing.In the 14th century, yersinia pestis killed more than one-third of the population of Europe within a few. Yersinia pestis, the bacterium responsible for that plague pandemic, still persists in the environment among rodent and flea populations today, and human outbreaks regularly occur around the world Yersinia pestis, Enterobacteriaceae ailesine mensup bir Gram negatif bakteri türüdür. Veba hastılığının üç türüne de (bubonik, pnömonik, septisemik) yol açar. Y. pestis tarih boyunca birçok pandemilere (1347-1353 arasındaki Kara Ölüm gibi) sebep olmuştur. Yersinia cinsine mensup bakteriler, Gram negatif çubuk şekilli kokobasillerden oluşmuştur ve diğer.

Yersinia pestis הוא חיידק גראם-שלילי, אל-אווירני פקולטטיבי, בעל צורת מתג המשתייך למשפחת ה-Enterobacteriaceae, שנצבע באופן דו-קוטבי (מה שמקנה לו מראה של סיכת ביטחון).בתור הגורם המחולל את מחלת הדבר, הדבקה בחיידק זה יכולה לגרום לדבר בובוני. Plague is an infectious disease caused by the bacterium Yersinia pestis. Symptoms include fever, weakness and headache. Usually this begins one to seven days after exposure. There are three forms of plague, each affecting a different part of the body and causing associated symptoms

Plague and its forms caused by Yersinia pestis - The

Yersinia pestis/Plague. The plague is a bacterial infection caused by Yersinia pestis ( Y. pestis ), which primarily infects rodents. The disease is transmitted to humans via a fleabite. Inhalation of infectious droplets and handling infected animals or laboratory specimens are other means of transmission. The plague has 3 forms: bubonic (most. Yersinia pestis Plague and the Black Death! Classic Case: Bubonic Plague. A middle aged male presents with extreme malaise, chills, a fever of 40°C, a painful swollen nodule in his left armpit. He works outside as a hunting guide in New Mexico Plague due to Yersinia pestis. updated February 2021 The Yersinia pestis infection guidelines were first published in the J Feline Med Surg 2013; 15: 582-584 by Maria Grazia Pennisi et al. The present guidelines were updated by Maria Grazia Pennisi. Key points. Plague is a severe bacterial disease of humans and other mammals caused by Yersinia pestis

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Yersinia pestis strains isolated in natural plague foci of

Overview of Plague. First Described: Descriptions of plague date back to around 1300 bc.The causative agent was isolated in 1894, in Hong Kong (Alexandre Yersin). 1 Cause: Yersinia pestis, a gram-negative coccobacillus (family Enterobacteriaceae) Affected Hosts: Y. pestis causes disease in rodents, rabbits, wild carnivores, domestic dogs and cats, and humans Yersinia pestis in found in animal reservoirs, especially in rodents which are often responsible for the rapid spread of the disease. Natural foci of plague are found all over the world, particularly in tropical and sub-tropical latitudes and in warm regions of the temperate latitudes Yersinia pestis is a vector-borne pathogen. People usually get infected by being bitten by fleas that carry the bacteria. These fleas are carried by rodents. In the Middle Ages, human homes and places of work were inhabited by rats that carried plague infected fleas. For more information about the Black Death email us here Yersinia pestis Agent Information Sheet. Print. On this page: Agent, Information for Lab Workers, Information for First Responders/Medical Personnel. Bubonic plague may occur 2-8 days after the bite of an infected flea with rapid onset of symptoms of high fever, severe malaise, headache,. Yersinia pestis (Y. pestis) is the causative agent of plague that evolved from a relatively benign pathogen—Yersinia pseudotuberculosis—thousands of years ago 1,2,3,4.Whilst plague is a.

Ecology and Transmission Plague CD

The bacterium Yersinia pestis is among the most virulent pathogens known to cause disease in humans. As the agent of plague it is an existing threat to public health as the cause of both emerging and re-emerging rodent-derived epidemics in many regions of the world (Duplantier et al., 2005; Vogler et al., 2011; Gage and Kosoy, 2005).This, and its confirmed involvement in three major historical. Plague, which is caused by the Gram-negative bacterium Yersinia pestis, is a disease that emerged relatively recently.Well known historically for the millions of deaths it has caused, this disease has profoundly changed our societies politically, economically and culturally Plague is a deadly infectious disease caused by the bacterium Yersinia pestis 1,2.Post-genomic analyses confirmed that Y. pestis was derived from the environmental bacteria Yersinia. Abstract. The guiding methodological principle of the modern molecular genetic (MG) approach to the problem of speciation of the plague bacteria Yersinia pestis is the saltationist paradigm of horizontal gene transfer. The main speciation events include the insertion of two virulence plasmids specific to Y. pestis, pFra and pPst, into the genome of ancestral psychrophilic saprozoonotic.

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Plague (Yersinia Pestis) Medically reviewed by Drugs.com. Last updated on May 5, 2021. Health Guide; What is the Plague (Yersinia Pestis)? Plague is caused by Yersinia pestis bacteria. It can be a life-threatening infection if not treated promptly. Plague has caused several major epidemics in Europe and Asia over the last 2,000 years Yersinia pestis , the cause of bubonic plague, is transmitted by the bites of infected fleas. Biological transmission of plague depends on blockage of the foregut of the flea by a mass of plague bacilli. Blockage was found to be dependent on the hemin storage ( hms ) locus. Yersinia pestis hms mutants established long-term infection of the flea's midgut but failed to colonize the. Yersinia pestis, the cause of plague, is a recently emerged clone of Yersinia pseudotuberculosis. PNAS. P.P. Flaquet (2010). The plague, a reemerging infectious disease. Cuban Journal of Comprehensive General Medicine. T. Butler (1983). Plague and other Yersinia infections. Plenum Press (New York) However, if Yersinia pestis enters through a flea bite, such as bubonic plague, the incubation period is 2 to 6 days. Again, during this time the damage response does not change. After the incubation period, the abrupt onset of initial symptoms, such as fever, headache, and chills, pushes the damage response sharply up Yersinia Pestis causes a thing we know as the plague. Yersinia Pestis is a bacteria based pathogen. The Y in pestis is extremely harmful pathogen that is likely to cause a severe sickness, infection, or even death. People can live for a short time with the disease but will most likely die if not treated right away